The end to a long and complicated story
Thanks for a clear and complete review. But.. your definition of stopping a trial for futility isn't quite right. "Futility" doesn't mean the data demonstratenthat the drug doesn't work, just that the current trial (if it were completed) has little chance of showing that the treatment does work. Reviewed here: https://evidence.nejm.org/doi/abs/10.1056/EVIDctw2100020#:~:text=Abstract,low%20to%20support%20meaningful%20comparisons.
Fair point, I've updated the language slightly to "are not showing evidence of a benefit" which is more correct and still understandable.
Actually I added "and is not likely to in the future" as well, just to make it clear. Thanks for pointing that out!
Thanks for a clear and complete review. But.. your definition of stopping a trial for futility isn't quite right. "Futility" doesn't mean the data demonstratenthat the drug doesn't work, just that the current trial (if it were completed) has little chance of showing that the treatment does work. Reviewed here: https://evidence.nejm.org/doi/abs/10.1056/EVIDctw2100020#:~:text=Abstract,low%20to%20support%20meaningful%20comparisons.
Fair point, I've updated the language slightly to "are not showing evidence of a benefit" which is more correct and still understandable.
Actually I added "and is not likely to in the future" as well, just to make it clear. Thanks for pointing that out!